Dr Benjamin Schumann MÂ鶹AV
Winner: 2024 Chemistry Biology Interface early career prize: Norman Heatley Award
Imperial College London and the Francis Crick Institute
For the creative use of chemistry-centred tools to provide valuable insights into glycan biology.
Celebrate Dr Benjamin Schumann
Collectively, the field is getting to a point where we will be able to study complicated biological processes in situ (as they happen) ...
Every single living cell in our bodies is covered by a layer of sugars that is normally the first thing a virus, bacterium, or a neighbouring cell interacts with. The structures of these sugars change when a cell changes its connections with the environment (for instance, when developing into a tumour). Understanding how these processes happen is essential to make better drugs and diagnostic markers for cancer. One such approach was equipping sugars with chemical functionalities that allow scientists to visualise them, for instance, by attaching a fluorescent molecule for microscopy. This paradigm-shifting ‘bioorthogonal chemistry’ led to the 2022 Nobel Prize in Chemistry to Bertozzi, Meldal and Sharpless.
Dr Schumann’s team uses bioorthogonal chemistry to make tools that are helping us to understand sugars. They develop molecules that tell us exactly how the sugar-building enzymes work – what they do and which sugars they build – out of the millions of structures that are found on a cell at any given point in time. Since many of these enzymes are important in diseases, such as neuronal disorders or cancer, the team’s chemical tools are a promising means of understanding what goes wrong in such conditions.
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