Overview:
Late Stage Functionalization (LSF) holds the potential to revolutionize the logic of chemical synthesis and open new ways to prepare novel natural products and medicines. The introduction of important chemical groups for medicinal chemistry in the very last steps of the synthesis through LSF could also dramatically speed up the preparation of NCEs and have a major impact on drug discovery. The availability of new powerful catalytic chemistries showing a high degree of functional group tolerance and that can be performed under mild conditions offer tremendous opportunities for chemists to access new molecules that cannot be made easily by conventional approaches.
Topics
Topics will cover hot and emerging areas in the field of late stage transformations (including C-H activation for total synthesis, oxidation, fluorination, alkylation, biocatalysts, transition metal catalysts, photoredox catalysts, late stage functionalization in medicinal chemistry, and late stage functionalization for PET chemistry).
Confirmed Speakers
The functionalization of C-H bonds
M Christina White, University of Illinois, Urbana-Champaign, USA
Late-stage fluorination
Tobias Ritter, Havard & Max Planck Institute, USA
Late stage fluorination: chemical, radiochemical and clinical advances
Véronique Gouverneur, University of Oxford, UK
C-H functionalization: a transformative technology for drug discovery
Shane Krska, Merck Rahway, USA
Cytochrome P450 monooxygenases in synthesis
Luet Wong, University of Oxford, UK
Ligand-accelerated C-H activation reactions: distance and geometry
Jin-Quan Yu, TSRI, USA
Features
Late Stage Functionalization (LSF) holds the potential to revolutionize the logic of chemical synthesis and open new ways to prepare novel natural products and medicines. The introduction of important chemical groups for medicinal chemistry in the very last steps of the synthesis through LSF could also dramatically speed up the preparation of NCEs and have a major impact on drug discovery. The availability of new powerful catalytic chemistries showing a high degree of functional group tolerance and that can be performed under mild conditions offer tremendous opportunities for chemists to access new molecules that cannot be made easily by conventional approaches.
Topics
Topics will cover hot and emerging areas in the field of late stage transformations (including C-H activation for total synthesis, oxidation, fluorination, alkylation, biocatalysts, transition metal catalysts, photoredox catalysts, late stage functionalization in medicinal chemistry, and late stage functionalization for PET chemistry).
Confirmed Speakers
The functionalization of C-H bonds
M Christina White, University of Illinois, Urbana-Champaign, USA
Late-stage fluorination
Tobias Ritter, Havard & Max Planck Institute, USA
Late stage fluorination: chemical, radiochemical and clinical advances
Véronique Gouverneur, University of Oxford, UK
C-H functionalization: a transformative technology for drug discovery
Shane Krska, Merck Rahway, USA
Cytochrome P450 monooxygenases in synthesis
Luet Wong, University of Oxford, UK
Ligand-accelerated C-H activation reactions: distance and geometry
Jin-Quan Yu, TSRI, USA
Features
- Six lectures delivered by leading scientists in the field
- Poster session and award for best poster
- Some posters selected for brief flash presentations
- Round table discussion at the end of the symposium
- A related trade exhibition
- Drinks reception
- Discounted rates are offered to Â鶹AV members, and some bursaries are available
